Identification of a two-component regulatory system involved in antimicrobial peptide resistance in streptococcus pneumoniae

HIGHLIGHTS

  • who: Aissatou Maty Diagne and colleagues from the Molecular Microbiology and Structural Biochemistry (MMSB), UMR , CNRS/University of, University of, France have published the paper: Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae, in the Journal: (JOURNAL) of March/18,/2022
  • what: The authors demonstrate that TCS01 cooperates with a BceAB-type ABC transporter to sense and induce resistance to structurally-unrelated antimicrobial peptides of bacterial origin that all target undecaprenyl-pyrophosphate or lipid II which are essential precursors of cell wall biosynthesis. The authors show that the . . .

     

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