HIGHLIGHTS
- who: Arenaviridae et al. from the CNRS u2013 UMR-7257, France, and bEuropean Bioinformatics Center, Leutragraben, Jena have published the Article: Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate, in the Journal: IUCrJ (2022). 468-479 of /2022/
- what: In the Thi Hong Van Nguyen et_al Arenaviridae nucleoprotein exonuclease this study shows that it is a moderate inhibitor in_vitro, and it is proposed that pyrophosphate analogs might constitute promising lead molecules for the development of antivirals against the arenavirus exonuclease. The authors report four crystallographic structures of MOPV NP-exo: one in complex with an Mn2 . . .
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