Smoc2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating myo1c

HIGHLIGHTS

• who: Di Liu from the We next explored the underlying mechanisms by which , controls MYO C expressionSince our data showed that , knockdown reduced MYO C mRNA expression, we first explored whether , modulated MYO C gene transcription. We found that the transcription factor , could activate the transcriptional activity of the MYO C promoter and positively regulate MYO C mRNA expression, and , knockdown decreased , expression, suggesting that , controls MYO C expression through SOX4-mediated gene transcription. Consistent with our findings, previous studies have shown that , is a critical transcription factor involved in the progression of multiple cancers, and it . . .
  

   

  

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