Impairment of foxm1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis

HIGHLIGHTS

• who: Giulia Falconi from the DepartmentUniversity of have published the article: Impairment of FOXM1 expression in mesenchymal cells from patients with myeloid neoplasms, de novo and therapy-related, may compromise their ability to support hematopoiesis, in the Journal: Scientific Reports Scientific Reports
• what: The authors show for the first time that downregulation of FOXM1 and of his mitotic targets may contribute to the disrupted BM microenvironment observed in MN. The authors show that FOXM1 is downregulated in BM-MSC isolated from AML and MDS patients, both de novo and therapy-related, as compared to healthy . . .
  

   

  

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