HIGHLIGHTS
- who: Sida Shen and colleagues from the Department of Chemistry and Center for Developmental Therapeutics, Northwestern University, Evanston, IL, USA have published the research work: Structural and Mechanistic Basis for the Inactivation of Human Ornithine Aminotransferase by (3S,4S)-3-Amino-4-fluorocyclopentenecarboxylic Acid, in the Journal: Molecules 2023, 1133 of 23/01/2023
- what: The authors performed theoretical pKa energy compared with intermediate M16. Supported by molecular docking and free_energy calculations, the authors propose the potential existence of an enolate intermediate that might be converted from the carboxylate of 5 and participate in the . . .
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