HIGHLIGHTS
- who: Sultana Mehbuba Hossain and Michael R. Eccles from the Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin , have published the research work: Phenotype Switching and the Melanoma Microenvironment; Impact on Immunotherapy and Drug Resistance, in the Journal: (JOURNAL)
- what: While the 5-year survival rate is over 90% for localized melanoma, this drops to 16% for distant disease, indicating that metastasis is the main reason for poor outcomes . This model proposes a pro-proliferative role for MITF, driving an invasive to proliferative transition, but also, at very high MITF expression levels . . .
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