HIGHLIGHTS
SUMMARY
Lower handgrip strength has been associated with cognitive decline, hippocampal atrophy, and white matter lesions in both general and clinical populations.15,17-19 Interestingly, while muscle strengthening exercises might slow cognitive decline,20 very few studies have examined the association of handgrip strength with the risk of dementia, and so far no studies have investigated associations with mortality from all-cause dementia. Two studies showed handgrip strength as a predictor of incident Alzheimer disease,4,5 while another study found that lower handgrip strength was associated with an increased risk of dementia. I . . .
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