HIGHLIGHTS
- who: Wenji Piao from the Center forUniversity of Minnesota Cancer Center, Minneapolis, MN, USA have published the article: PD-L1 signaling selectively regulates T cell lymphatic transendothelial migration, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors demonstrated that Tregs and especially activated iTregs, preferentially expressed PD-1 to ligate PD-L1 for lymphatic transendothelial migration (TEM). Taken together, the authors propose the coexistence of both cis and trans binding of CD80 to PD-L1. The study provides previously undescribed functions for PD-1 or CD80-driven PD-L1 signaling in endothelial cells for . . .
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