HIGHLIGHTS
SUMMARY
The development and improvement of different chemotherapeutics for cancer treatment have been the main research topic of numerous groups worldwide. MDR is strongly correlated to the overexpression of ATP-binding cassette (ABC) transporters, yet other mechanisms such as altered drug metabolism, decreased drug uptake, or increased resistance to apoptosis, as well as drug compartmentalization, are known. Classified into subfamilies ABC A to ABC G, based on their structural similarity as well as their phylogenetic, ABC proteins are often associated with nutrient transport or expression in tissues with barrier function. Three of these transporters are . . .
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