P53-mediated indirect regulation on’cellular metabolism: from the mechanism of pathogenesis to the development of cancer therapeutics

HIGHLIGHTS

• who: Chen-Yun Wang from the Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, Center have published the research work: p53-Mediated Indirect Regulation onu0092Cellular Metabolism: From the Mechanism of Pathogenesis to the Development of Cancer Therapeutics, in the Journal: (JOURNAL)
• what: In the previous study , the authors demonstrate that miR-200c, a WTp53 target negatively regulating epithelialmesenchymal transition (EMT) and stemness , promotes OXPHOS in basal-like breast cancer (BLBC) cells by inhibiting the downstream targets, ZEB1 and BMI1, which subsequently activates PCK2 expression. Indirect approaches aim to disrupt . . .
  

   

  

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