Improved selection of zebrafish crispr editing by early next-generation sequencing based genotyping

HIGHLIGHTS

• who: Ewa Sieliwonczyk from the FacultyUniversity of have published the article: Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping, in the Journal: Scientific Reports Scientific Reports
• what: For the CRISPR -Cas9 experiments, the authors focused on two known mutations in the CACNA1C gene: c.2570C>G or p.(Pro857Arg), corresponding to c.2607C>G or p.(Pro871Arg) in zebrafish, associated with a long QT syndrome (LQTS) u00adphenotype19 and c.989C>T or p.(Thr330Met), corresponding to c.1028C>T or p.(Thr343Met) in zebrafish, associated with Brugada syndrome (BrS)20 . . .
  

   

  

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