Gpx4-independent ferroptosis—a new strategy in disease’s therapy

HIGHLIGHTS

• who: Tianyu Ma from the DepartmentMedical University have published the research: GPX4-independent ferroptosisu2014a new strategy in diseaseu2019s therapy, in the Journal: (JOURNAL) of 12/07/2022
• what: This research has not clarified how cells die during ferroptosis.
• future: It is an issue that future research needs to address.

SUMMARY

Overexpression of FSP1 effectively inhibited ferroptosis in HT1080 cells but failed to inhibit ferroptosis in COQ2-deficient cells, which indicates that the anti-ferroptosis effect of FSP1 is dependent on CoQ10. The myristoylated FSP1 can be recruited into the . . .

 



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