HIGHLIGHTS
- who: Su-Yu Ji from the (UNIVERSITY) have published the article: Molecular basis for the activation of thyrotropin-releasing hormone receptor, in the Journal: (JOURNAL)
- what: The authors report the high-resolution cryo-electron microscopy (cryo-EM) structure of the TRH-bound TRHR-Gq signaling complex. Compared with the recent two related studies5,6, the work provides additional structural and functional details.
SUMMARY
TRHR is mainly expressed in the anterior pituitary where it modulates the synthesis and release of thyroidstimulating hormone and prolactin via mediating the actions of thyrotropin-releasing hormone . . .
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