Gata 2 deficiency: focus on immune system impairment

HIGHLIGHTS

  • who: Francesco Fabozzi from the Department of Hematology/Oncology, Cell and Gene Therapy, Bambino Gesu00f9 Children`s Hospital, Rome, Italy, Ghent University, Belgium have published the paper: GATA 2 Deficiency: Focus on Immune System Impairment, in the Journal: (JOURNAL)
  • what: Germline mutations of GATA2 cause a various and complex clinical phenotype, including immunodeficiency, bone marrow failure, lymphedema, deafness, and pulmonary dysfunction.
  • future: Research is needed to find other effective treatments other than HSCT.

SUMMARY

    GATA family includes six nuclear transcriptional factors sharing the ability to bind to the consensus . . .

     

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