Midkine-notch2 pathway mediates excessive proliferation of airway smooth muscle cells in chronic obstructive lung disease

HIGHLIGHTS

  • who: Midkine-Notch and colleagues from the Department of Interventional radiology and vascular surgery, The First Affiliated Hospital of Hainan Medical University, Hainan and Children`s Medical Center, Haikou, China have published the research: Midkine-Notch2 Pathway Mediates Excessive Proliferation of Airway Smooth Muscle Cells in Chronic Obstructive Lung Disease, in the Journal: (JOURNAL)
  • what: In this work, the role of MKNotch2 signaling in COPD was explored by inhibiting the expression of MK using lentivirus shRNA in ASMCs in_vitro and instillation of AAV9-MK in the airway of a COPD rat model in_vivo. The study . . .

     

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