Aggregated alpha-synuclein inclusions within the nucleus predict impending neuronal cell death in a mouse model of parkinsonism

HIGHLIGHTS

  • who: Leah J. Weston and collaborators from the Department of Neurology and Jungers Center for Neurosciences Research, Oregon Health and Science University, Portland, OR, USA have published the research work: Aggregated Alpha-Synuclein Inclusions within the Nucleus Predict Impending Neuronal Cell Death in a Mouse Model of Parkinsonism, in the Journal: (JOURNAL)
  • what: The authors aimed to better understand the role of nuclear inclusions in disease pathology using a mouse model that develops nuclear inclusions and an analysis of synucleinopathy patient tissue. This analysis demonstrated that NNIs with specific morpholofraction bearing NNIs that died in . . .

     

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