HIGHLIGHTS
- who: Takuro Horii from the (UNIVERSITY) have published the research: Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system, in the Journal: (JOURNAL)
- what: The authors attempted to generate epigenetic disease model mice by targeted DNA demethylation using the PB transposon system, which enabled efficient transgene integration and high animal viability.
SUMMARY
Hypermethylated DNA regions are usually linked to silenced and inactive chromatin, while hypomethylated DNA regions are generally associated with gene_expression and open chromatin. Targeted DNA demethylation of hypermethylated regions to reactivate silenced genes . . .
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