Multienzyme interactions of the de novo purine biosynthetic protein paics facilitate purinosome formation and metabolic channeling

HIGHLIGHTS

• who: Jingxuan He from the (UNIVERSITY) have published the research: Multienzyme interactions of the de novo purine biosynthetic protein PAICS facilitate purinosome formation and metabolic channeling, in the Journal: (JOURNAL) of November/11,/2021
• what: The authors show these interactions are present in cells grown in both purine-depleted and purine-rich conditions, suggesting at least a partial assembly of these enzymes may be present regardless of the activity of the DNPB pathway. The authors show that crPAICS cells with reintegrated N-terminally tagged PAICS regained effective DNPB with metabolic signatures of channeled synthesis, whereas . . .
  

   

  

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