Prediction of pathogenic factors in dysbiotic gut microbiomes of colorectal cancer patients using reverse microbiomics

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    Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and dysregulated immune_response. The taxonomy ID, rank, location, April 2022 | Volume 12 | Article 882874 CRC-Associated Gut Microbiomes Pathogenic Factors protein sequences of the representative strains in these species. Among the 4,278 proteins, 2,440 proteins were conserved among five enriched genomes of B. fragilis and B. ovatus, and 77 proteins were predicted to be absent from the 11 depleted genomes of B. finegoldii, B. intestinalis, and B. uniformis. By including only those proteins . . .

     

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