The timing of differentiation and potency of cd8 effector function is set by rna binding proteins

HIGHLIGHTS

• who: Georg Petkau from the Department University Medical have published the paper: The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 30/03/2022
• what: The authors show ZFP36 and ZFP36L1 function during an early temporal window after activation in CD8+ T_cells to limit the tempo of effector differentiation and the functional capacity of differentiated effector cells. The authors show, using nau00efve mouse CD8+ T_cells, that ZFP36 and ZFP36L1 regulate Il2 directly via binding to IL-2 mRNA and promoting . . .
  

   

  

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