Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus rnaseq are rescued by thiamine-biotin supplementation

HIGHLIGHTS

• who: Ryan G. Lim from the All research conducted for this study complies with all relevant ethical regulations including IACUC approval protocol #s AUP-18, and, ASRC-2022, and the Columbia University IRB protocol # AAAT Human brain tissues from HD and non-HD patient autopsies, which were diagnosed based on accepted neuropathological criteria, were obtained from the New York Brain Bank. All brains were donated after consent from the next of kin or an individual with legal authority to grant such permission. The use of postmortem brain tissues for research was approved by the Columbia University Institutional . . .
  

   

  

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