Ifnγ binding to extracellular matrix prevents fatal systemic toxicity

HIGHLIGHTS

• who: Josephine Kemna from the (UNIVERSITY) have published the research work: IFNu03b3 binding to extracellular matrix prevents fatal systemic toxicity, in the Journal: (JOURNAL) of 21/06/2022
• what: The authors show that IFNu03b3 lacking the EBD (IFNu03b3u0394KRKR) does not bind to ECM but still binds to the IFNu03b3R and retains bioactivity.
• how: Because of the strong evolutionary conservation of the KRKR motif in the IFNu03b3 protein the authors investigated its relevance in in_vivo models. and no conserved ligand-IFNu03b3R interaction motifs13.
• future: In models of transient IFNu03b3 production the EBD . . .
  

   

  

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