HIGHLIGHTS
- who: CIC and colleagues from the University of Padua, Italy have published the paper: ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth, in the Journal: (JOURNAL)
- what: The authors aimed to evaluate ERK, p90RSK, and c-SRC for their contribution to the EGFR activation-induced cytoplasmic translocation of CIC and further investigated the molecular basis for this process. The authors showed that nuclear ERK plays a key role in the cytoplasmic translocation of CIC-S in mammals. The study demonstrated that blocking the cytoplasmic translocation of . . .
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