HIGHLIGHTS
- who: Bing-Yao Sun from the East China University Science Technology, Shanghai, China have published the Article: Structure-guided engineering of a flavin-containing monooxygenase for the efficient production of indirubin, in the Journal: (JOURNAL)
- what: This approach provided an efficient highthroughput screening method for FMOs via the selection of positive mutants for indirubin production. The authors aimed to further identify functional hotspots beyond the active_sites in the substrate pocket for the creation of smart mutant libraries. The structural refinement of the models was performed by energy minimization, and molecular dynamics simulations were conducted for . . .
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