Inhibition of autophagy by chloroquine prevents resistance to pi3k/akt inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

HIGHLIGHTS

• who: Stefania Cocco from the Department of Breast and Thoracic Oncology, Division of Breast Medical , Naples, Italy have published the Article: Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models, in the Journal: (JOURNAL)
• what: The aim of this study was to evaluate the antitumor activity of PI3K or AKT inhibitors plus CQ, to prevent authophagy -mediated mechanism of resistance, in combination with taxanes.
• how: The authors showed synergistic antitumor effect by using low dosages of . . .
  

   

  

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