HIGHLIGHTS
SUMMARY
Mutations to downstream changes in gene_expression and cellular function within individual tumor samples. Enabled by this publicly available data, a growing body of work on linking the presence of driving genetic alterations in cancer to downstream gene_expression changes has emerged. More broadly, other groups have drawn on similar ideas to distinguish between the functional effects of different alterations in the same driver gene, to link alterations with similar gene_expression signatures within cancer types, and to identify trans-acting expression quantitative trait loci (trans-eQTLs) in germline genetic studies. Correlation between gene_expression and protein abundance . . .
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