Emergence of synchronized multicellular mechanosensing from spatiotemporal integration of heterogeneous single-cell information transfer

HIGHLIGHTS

SUMMARY

Previously, the authors demonstrated that cell-cell communication through gap junctions modulated ATP-induced calcium signaling in monolayers of fibroblast cells 14. Upon changing the flow rate (e_g, during acute wound), endothelial cells detect the change in shear stress, inform other cells such as smooth muscle cells, and adjust their internal signaling accordingly. Division of labor, where single cells take differentiated functional roles in collective information processing; Cell memory, where single cells maintain and reinforce their specified functional roles in cell-cell communication in response to repeated external stimuli; And information flow, where the . . .

 



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