HIGHLIGHTS
- who: Caroline Dour from the (UNIVERSITY) have published the paper: Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations, in the Journal: (JOURNAL) of 13/Oct/2021
- what: The authors show that in muscle cells carrying a cardiomyopathy-causing LMNA mutation, phospho(T25)-cofilin-1 binds to myocardin-related transcription factor A (MRTF-A) in the cytoplasm, thus preventing the stimulation of serum response factor (SRF) in the nucleus. The authors show for the first time an actinmicrotubule cytoskeletal interplay mediated by cofilin-1 and MRTF-A . . .
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