HIGHLIGHTS
- who: Chunfang Yang from the (UNIVERSITY) have published the research: Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation, in the Journal: (JOURNAL) of 13/Dec/2021
- what: The authors show that the flavoprotein monooxygenase FlsO1 in the biosynthesis of fluostatins not only functionally compensates for the monooxygenase FlsO2 in converting prejadomycin to dehydrorabelomycin, but also unexpectedly converts prejadomycin to xanthonecontaining products by catalyzing three successive oxidations including hydroxylation, epoxidation and Baeyer-Villiger oxidation. The authors show that FlsO1 catalyzes an unexpected conversion of PJM to multiple products including DHR . . .
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