The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting th17 differentiation

HIGHLIGHTS

  • who: Katie J. Smith and collaborators from the Centre for Inflammation Research, University of Edinburgh, Edinburgh, United, Centre for have published the research work: The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation, in the Journal: (JOURNAL)
  • what: Now the authors report that severe EAE disease. The authors show that is produced by same cell types in active brain lesions in human MS disease. The authors propose that exposure results in highly activated cytokine-producing T cells which drive autoimmunity; this is mechanism through which neutrophils amplify inflammation . . .

     

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