Gasdermin d inhibition ameliorates neutrophil mediated brain damage in acute ischemic stroke

HIGHLIGHTS

• who: Ruiyao Hu from the Mice and treatments Adult wild-type (WT) C BL/ J mice were purchased from SPF Biotechnology Co(Beijing, China). C BL/ J GSDMD-/- (global knockout) mice were purchased from Shanghai Model Organisms Center, Inc (Shanghai, China). Knockout of the GSDMD gene was validated by genotyping and immunoblotting. All animal surgeries were performed on male mice aged, weeks and weighing, g. Each group of mice was allocated at random. All animals were housed in a pathogen-free environment in the Zhengzhou University Animal Facility and were given ad libitum access to food and . . .
  

   

  

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