HIGHLIGHTS
- who: Douglas P. Wightman from the Department have published the research work: Rare variant aggregation in 148,508 exomes identifies genes associated with proxy dementia, in the Journal: Scientific Reports Scientific Reports
- what: This analysis shows that the associations of TREM2, and TOMM40 with proxy AD/dementia was driven by variants with moderate associations (P and amp;lt; 1 u00d7 u00ad10-4) and MAC > 5, where SORL1 was influenced by low MAC variants ( and amp;lt; 5) and moderately associated variants, but not singletons. This may be due to some of the previous studies focusing . . .
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