Antiangiogenic drugs in combination with seaweed fucoidan: a mechanistic in vitro in vivo study exploring the vegf receptor and its downstream signaling molecules in hepatic cancer

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SUMMARY

Some of the reported biological activities of fucoidan include antiviral, anticoagulant, anti-inflammatory, antioxidant and antihyperlipidemic (Cumashi et_al, 2007; Li et_al, 2008; Lira et_al, 2011; Abdollah et_al, 2018). Fucoidan is a sulphated polysaccharide consisting mainly of fucose and sulfate ester groups (Cumashi et_al, 2007; Li et_al, 2008). To being consumed in traditional Asian diet (particularly in China, Korea and Japan), it is commercially available as an over the counter (OTC) herbal food supplement in many western countries (Fitton, 2011; Atashrazm et_al, 2015). The diverse pharmacological actions of fucoidan are still under investigation but it . . .

 



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