HIGHLIGHTS
- who: Fabio Vanoli from the (UNIVERSITY) have published the research work: Generating in vitro models of NTRK-fusion mesenchymal neoplasia as tools for investigating kinase oncogenic activation and response to targeted therapy, in the Journal: (JOURNAL) of 23/09/2022
- what: Employing a similar methodology used to model the desmoplastic small round cell tumor EWSR1::WT1 fusion , the authors aimed to fuse ETV6 exons 1-5 to NTRK3 exons 15-19 in hES cells (Fig 3B). These characteristics could explain, for example, why the models show similar sensitivity to both drugs despite the different concentrations . . .
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