Presenilin 1 deficiency impairs aβ42-to-aβ40- and angiotensin-converting activities of ace

HIGHLIGHTS

• who: ufeffYuanufeff ufeffGaoufeff and collaborators from the Institute of Biochemistry and Cell Biology, National Research Council (CNR), Italy Okayama University of Science, Japan have published the article: Presenilin 1 deficiency impairs Au03b242-to-Au03b240- and angiotensin-converting activities of ACE, in the Journal: (JOURNAL) of 17/02/2023
• how: The authors hypothesized that the increase in the Au03b242/40 ratio associated with PSEN1 mutations results from impairment of the Au03b242-to-Au03b240-converting activity of ACE. The authors examined whether PS1 can regulate the activity of ACE which converts neurotoxic Au03b242 to neuroprotective Au03b240.
 



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