Sequential hydrozirconation/pd-catalyzed cross coupling of acyl chlorides towards conjugated (2e,4e)-dienones

HIGHLIGHTS

  • who: Benedikt Kolb and colleagues from the Institut fu00fcr Organische Chemie, Universitu00e4t Stuttgart, Pfaffenwaldring, Stuttgart, Germany have published the paper: Sequential hydrozirconation/Pd-catalyzed cross coupling of acyl chlorides towards conjugated (2E,4E)-dienones, in the Journal: (JOURNAL)
  • what: Based on initial results by Cox on the sequential hydrozirconation/Pd-catalyzed acylation of alkynes with acyl chlorides, the scope was extended towards a novel stereospecific dienone synthesis starting from enynes 25 and acyl chlorides 26.
  • how: To optimize the second step of the reaction sequence several Pd complexes were tested in the reaction . . .

     

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