Traps mutations in tnfrsf1a decrease the responsiveness to tnfα via reduced cell surface expression of tnfr1

HIGHLIGHTS

• who: Takahiko Akagi from the Nagasaki University, Japan have published the article: TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFu03b1 via reduced cell surface expression of TNFR1, in the Journal: (JOURNAL)
• what: Based on the experimental and clinical findings, the authors propose that the G87V mutation is a pathogenic mutation causing TRAPS . The authors tested the effect of TNFa on the secretion of inflammatory cytokines from TRAPS PBMCs and found that TNFa did not enhance the secretion of inflammatory cytokines compared with that in compared with WT mice, whereas Simon et_al showed that heterozygotes . . .
  

   

  

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