HIGHLIGHTS
- who: Tal Fisher from the Weizmann Institute The University of Texas Medical Branch, Galveston, TX, USA have published the article: Parsing the role of NSP1 in SARS-CoV-2 infection, in the Journal: (JOURNAL) of June/14,/2022
- what: By overexpressing various mutants and generating a SARS-CoV-2 mutant the authors show that through inhibition of translation and induction of mRNA degradation targets translated cellular mRNA and is the main driver of host shutoff during infection. The authors show that nsp1-wild_type (WT), but not nsp1-DRB, associates with ribosomes . The analysis shows that . . .
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