Mechanistic insights into the activation of the ikk kinase complex by the kaposi`s sarcoma herpes virus oncoprotein vflip

HIGHLIGHTS

• who: Claire Bagnu00e9ris from the (UNIVERSITY) have published the research work: Mechanistic insights into the activation of the IKK kinase complex by the Kaposi`s sarcoma herpes virus oncoprotein vFLIP, in the Journal: (JOURNAL) of August/10,/2021
• what: Using a combination of cell-based assays, biophysical techniques, and structural biology, the authors demonstrate here that vFLIP alone is sufficient to activate the IKK kinase complex.

SUMMARY

Although the physical interaction between vFLIP and the IKK kinase regulatory component essential for persistent activation, IKKγ, has been well characterized, it remains unclear . . .

 



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