Picasso allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements

HIGHLIGHTS

• who: Junyoung Seo from the Korea Advanced Institute Sungkyunkwan University have published the paper: PICASSO allows ultra-multiplexed fluorescence imaging of spatially overlapping proteins without reference spectra measurements, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors propose a non-reference-based unmixing technique called PICASSO (Process of ultra-multiplexed Imaging of biomoleCules viA the unmixing of the Signals of Spectrally Overlapping fluorophores), which can blindly unmix images without reference emission spectra, enabling multiplexed imaging of 15 proteins in the brain in a single staining and imaging round. By combining PICASSO with an antibody . . .
  

   

  

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