Structural insights into cas9 mismatch: promising for development of high-fidelity cas9 variants

HIGHLIGHTS

• who: Honghai Tang from the ENT InstituteUniversity, Shanghai, China have published the research: Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants, in the Journal: (JOURNAL) of 19/07/2022

SUMMARY

Received Structural insights into Cas9 mismatch: promising for development of... In these structures, only the ternary complexes may be suitable for exploring the off-target effects of Cas9. Their DNA substrates are only on-target DNA double strands without mismatch. And except 6O0Y the residues Asp10 and His840 of the catalytic centers in the other structures are mutated . . .

 



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