HIGHLIGHTS
- who: Changchang Xin from the (UNIVERSITY) have published the research work: Comprehensive assessment of miniature CRISPR-Cas12f nucleases for gene disruption, in the Journal: (JOURNAL) of 14/09/2022
- what: The authors apply a high-throughput sequencing method to comprehensively assess the editing efficiency, specificity, and safety of four Cas12f proteins in parallel with that of Cas9 and two Cas12a proteins at multiple genomic sites.
- how: To comprehensively evaluate the effects of these Cas nucleases the authors calculated the editing safety score of these enzymes by combining their off-target activity with the . . .
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