Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression

HIGHLIGHTS

• who: Thomas Parmentier from the DepartmentUniversity of have published the research work: Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression, in the Journal: Scientific Reports Scientific Reports
• what: The authors focused on 9 miRNAs previously demonstrated to participate in neurogenesis and consistently differentially expressed in rodent models of epilepsy as well as human epileptic u00adtissue31.

SUMMARY

Different protocols have been used to generate cerebral organoids from human pluripotent stem_cells. This protocol has been shown to reliably generate cerebral organoids termed "cortical spheroids" by . . .

 



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