Whole genome sequencing identifies novel mutations associated with bedaquiline resistance in mycobacterium tuberculosis

HIGHLIGHTS

  • who: Qinglong Guo from the Federal of Su00e3o Paulo, Brazil have published the Article: Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis, in the Journal: (JOURNAL)
  • what: In the present study, to better characterize the mechanisms of BDQ resistance, the authors identified 1,025 BDQ-resistant mutants from approximately 5u00d7109 bacteria. The study provided new perspectives on the mechanisms of resistance to BDQ by confirming that glpK, a previously undetermined gene, is involved in BDQ resistance.
  • how: The results showed that most BDQ-resistant mutants (86/101) with . . .

     

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