HIGHLIGHTS
- who: Chi-Che Hsieh from the Received: , February , Revised: , July , Accepted: , August , Published online: , August , Published on Behalf of CR UK have published the article: CHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer, in the Journal: (JOURNAL)
- how: Next the authors examined whether the activation of PARP1 is dependent on CHK2 activity. These results indicated that the kinase activity of CHK2 plays an important role in overcoming the cytotoxic effects of oxaliplatin. These results showed that phosphorylation of CHK2 at T68 is crucial for developing oxaliplatin resistance. The authors evaluated the . . .
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