HIGHLIGHTS
- who: Qifei Li and colleagues from the DivisionStrasbourg University, Illkirch, France have published the article: Dynamin-2 reduction rescues the skeletal myopathy of SPEG-deficient mouse model, in the Journal: (JOURNAL)
- what: The aim of the study was to test if DNM2 reduction can be an effective strategy to rescue SPEG deficiency. The rationale included: 1) MTM1, DNM2, BIN1, and SPEG mutations cause CNM ; 2) mouse models of CNM genes show an abnormal triad structure and defective calcium handling in skeletal muscles ; and 3) in this study the authors show that DNM2 levels were increased . . .
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