HIGHLIGHTS
- who: Joshua T. Lange from the DepartmentStanford University for Evolutionary Biology, Plu00f6n, Germany have published the paper: The evolutionary dynamics of extrachromosomal DNA in human cancers, in the Journal: (JOURNAL) of 16/02/2022
- what: The authors integrated computer simulations mathematical modeling evolutionary theory unbiased image analysis CRISPR-based ecDNA tagging with live-cell imaging and CRISPR-C to generate ecDNA as well as longitudinal analyses of patients` tumors (Extended Data Fig 1a) to better understand ecDNA inheritance and its functional consequences.
- how: The authors developed a FISH-based method combined with unbiased . . .
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