HIGHLIGHTS
SUMMARY
Subclinical target organ damage (TOD) refers to the structural and functional alterations of the cardiovascular system associated with unhealthy risk factors, among which systemic hypertension stands out. Asymptomatic alterations of the cardiovascular system reflect an intermediate step in the disease continuum linking hypertension and coexistent risk factors, such as dyslipidemia, obesity, and diabetes_mellitus, to non-fatal and fatal cardiovascular events. Hypertensive heart disease represents one of the most important manifestations of subclinical TOD due to its high prevalence, possibly related to the early onset of this adverse phenotype in the natural history of hypertension . . .
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