Microglial nf-κb drives tau spreading and toxicity in a mouse model of tauopathy

HIGHLIGHTS

• who: Chao Wang from the Gladstone InstituteUniversity of Medicine, Bronx, NY, USA have published the paper: Microglial NF-u03baB drives tau spreading and toxicity in a mouse model of tauopathy, in the Journal: Neurology,
• what: The authors show that microglial NF-u03baB activation is required for microglial-mediated tau spreading and tau-mediated spatial learning and memory deficits in tauopathy mice (Fig 8). The study shows that in PS19 mice, exogenous tau inoculation-induced tau seeding was accelerated by microglial NF-u03baB activation, but diminished by NF-u03baB inactivation. Taken together, the work shows that . . .
  

   

  

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