Rnf7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the socs1/jak/stat3 feedback loop

HIGHLIGHTS

• who: Chengwu Xiao from the Department of Urology, Medical University, No, Shanghai, China have published the Article: RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop, in the Journal: (JOURNAL)
• what: In the present study, the RNF7-SOCS1/JAK/STAT3 pathway was identified, and its functional importance in RCC progression was demonstrated. CCK-8 assay and flow cytometry analysis were conducted to assess the effects of RNF7 knockdown on cell viability and apoptosis, respectively. This study demonstrated that STAT3 directly regulates the RNF7 promoter . . .
  

   

  

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